CODA

For the treatment of appendicitis, antibiotics were noninferior to appendectomy on the basis of results of a standard health-status measure.

APPAC II

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis

Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics.

Vigorous Hydration to Manage Intermittent Claudication?

In an uncontrolled study, daily intake of 2500 mL of fluids was beneficial

prospective cohort study, this group has systematically examined the effect of hydration in 132 patients (median age, 72) with disabling intermittent claudication despite treatment with exercise, risk-factor modification, and cilostazol. Patients were instructed to drink 2500 mL of liquids daily (at baseline, average fluid intake was 1000 mL daily); they also were advised on dietary protein supplementation and moderate sodium intake. Patients with heart failure or whose serum creatinine was >1.5 mg/dL were excluded.

Median walking distance on a treadmill increased from 100 m at baseline to 535 m at 6 weeks. Median time to claudication increased from 1.3 to 6.3 minutes. These improvements persisted through 6 months