Endothelin receptor Antagonists

Ambrisentan

ARIES 1

6MWD improved TTCW not improved

Bosentan

BREATHE 1

6MWD improved TTCW improved

PDE 5 Inhibitors

Sildenafil

SUPER 1

6MWD improved TTCW not improved

Guanylate cyclase stimulators

Riociguat

PATENT

6MWD improved Haemodynamics improved

Prostacyclin analogues