Vit E?

PIVENS

Non DM, Biopsy proven NASH

Improves enzymes and histology

TONIC

Neither vitamin E nor metformin was superior to placebo in attaining the primary outcome of sustained reduction in ALT level in patients with pediatric NAFLD.

Daily dosing of 800 IU of vitamin E (58 patients), 1000 mg of metformin (57 patients), or placebo (58 patients) for 96 weeks

Obeticholic acid

REGENERATE

Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH.

The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes

Pioglitazone?

PIVENS

Non DM, Biopsy proven NASH

Improves enzymes

Rosiglitazone