Chronic Inflammatory Diseases Vary Widely in CHD Risk

SLE: hazard ratio for CHD, 2.85; for MI, 4.76.

Systemic sclerosis: HR for CHD, 2.14; for MI, 3.19.

HIV: HR for CHD, 1.38; for MI, 1.69.

Rheumatoid arthritis: HR for CHD, 1.22; for MI, 1.45.

Psoriasis: no significant increase.

RHAPSODY Rilonacept (Interleukin-1 Trap) Resolves, Prevents Pericarditis Recurrence

Among patients with recurrent pericarditis, rilonacept led to rapid resolution of recurrent pericarditis episodes and to a significantly lower risk of pericarditis recurrence than placebo

Transseptal SAPIEN 3 MViV was associated with rare procedural complications and low mortality and should be considered an option for most patients with failed surgical bioprosthetic mitral valves.

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death

A Review

SCD can occur earlier in the course of MVP from complex arrhythmias that are triggered by the repeated tugging and traction of the chordopapillary muscle unit and basal mid-myocardium, even before macrofibrosis can be identified in these regions by late gadolinium enhancement on cardiac magnetic resonance imaging

Vericiguat

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

VICTORIA

Among patients with high-risk heart failure, the incidence of death from cardiovascular causes or hospitalization for heart failure was lower among those who received vericiguat than among those who received placebo.

Omecamtiv Mecarbil

COSMIC-HF

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial

GALACTIC-HF