Primary prevention

In patients with very high LDL

WOSCOPS

Pravastatin reduced mortality as well as MI. ~LDL 192

In patients with average LDL

AFCAPS-TEXCAPS

Average cholesterol (LDL ~150) without ASCVD Lovasatin prevent acute coronary events

In patients with intermediate risk?

HOPE-3

Given statins without a specific target. Reduced events.

Base line ~130

In patients with normal LDL but increase hsCRP

JUPITER

In patients with normal LDL (LDL ~108) but increase hsCRP rosuvastatin reduced CV events

New onset DM were 270 vs 216 (p=o.01)