Primary prevention
In patients with very high LDL
WOSCOPS
Pravastatin reduced mortality as well as MI. ~LDL 192
In patients with average LDL
AFCAPS-TEXCAPS
Average cholesterol (LDL ~150) without ASCVD Lovasatin prevent acute coronary events
In patients with intermediate risk?
HOPE-3
Given statins without a specific target. Reduced events.
Base line ~130
In patients with normal LDL but increase hsCRP
JUPITER
In patients with normal LDL (LDL ~108) but increase hsCRP rosuvastatin reduced CV events
New onset DM were 270 vs 216 (p=o.01)