Stroke Thrombolysis

Alteplase

• 3hr

NINDS

ATLANTIS

• 3 - 4.5 hrs

ECASS III

• Wakeup Strokes

WAKE UP

• 3 - 6 hours

EPITHET

• 4.5 and 9.0 hours

EXTEND

Significantly better functional outcome and more ICH than placebo at 90 days.

Tenecteplase

Non-inferior to Alteplase

AT-TEST

TNK 0.25mg/kg within 4.5 hours

NOR-TEST

TNK 0.4 mg/Kg