Friday, October 23, 2020

9:14 AM

LABA + ICS or ICS/LABA alone?

TORCH

LABA+ICS result in reduced exacerbations and hospitalizations

No sig. reduction in death from all causes

Salmeterol, fluticasone

LAMA is good?

UPLIFT

Tiotropium (LAMA) reduced exacerbations in patients with moderate to severe COPD compared to placebo

But not PFT decline

LAMA is better?

LAMA > LABA for exac reduction

POET COPD

Tiotoprium > salmeterol

INVIGORATE

Tiotoprium > Indacaterol

LAMA is 1st line in COPD group C

LABA + LAMA or LABA+ICS?

FLAME