Stable CAD

DIAD - Detection of Ischemia in Asymptomatic Diabetics (DIAD)

Asymptomatic patients with diabetes, the cardiac event rates were low and were not significantly reduced by adenosine-stress radionuclide myocardial perfusion imaging (MPI) screening for myocardial ischemia over 4.8 years.

CKD pts were excluded in DIAD

CARSK -Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

Ongoing

Initial Invasive or Conservative Strategy for Stable Coronary Disease

ISCHEMIA (2020 NEJM)

Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used.

Stable coronary disease and moderate /severe ischemia initial invasive strategy NO benefit

Management of Coronary Disease in Patients with Advanced Kidney Disease

ISCHEMIA-CKD (2020 NEJM)

Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction.

Stable coronary disease with advanced CKD and moderate /severe ischemia initial invasive strategy NO benefit.